Growth hormone is a hormone produced by the pituitary gland and is one of the main regulators of human growth and development. The normal concentration of growth hormone in the blood is especially important for children from birth to puberty, since during this period it contributes to the proper growth of bones. The hormone is usually secreted into the blood in waves during the day with peak concentration usually at night. In the absence of growth hormone formation, the child grows more slowly. Excess growth hormone production is often seen with a pituitary tumor (usually benign). Excessive synthesis of the hormone contributes to excessive elongation of bones and continued growth even after puberty, which can lead to gigantism (growth over 2 meters). In adults, somatotropin is less active, but continues to play an appropriate role in the regulation of bone density, fatty acid metabolism and the maintenance of muscle mass.
Influence on bodily functions
Growth hormone regulates many functions in the body, including growth. Growth hormone acts through growth factors (IGF-1), which are produced primarily in the liver. Growth hormone also has effects independent of IGF. Some effects are even opposite to those of IGF, such as the effect on blood sugar. The independent anabolic effect of growth hormone is not entirely clear, it requires IGF-1 for effective action.
Growth hormone has a multifaceted effect on carbohydrate and fat metabolism. La hormone del crecimiento es una hormone anabólica (es decir, una hormone que estimula el crecimiento de los tejidos) that increases and transports from ciertos amino acids to the cells, will accelerate the síntesis of proteins and affect the metabolism of the fats and the balance of liquids in the body. Growth hormones enhance the muscle building effects of testosterone and anabolic steroids.
In medicine, growth hormone is used to treat children with growth disorders caused by insufficient secretion of growth hormone. In some cases, growth hormone is used to treat adults with severe growth hormone deficiency.
The diagnosis must be confirmed by the accurate use of different types of stress tests, which measure growth hormone secretion before starting use. A doctor can be accused of a therapeutic error if he prescribes growth hormones to a patient without seeing him or making a complete diagnosis.
The condition of patients receiving growth hormone should be carefully monitored, in particular, to determine the indicators of thyroid function and to conduct an examination to exclude a possible violation of glucose tolerance (impaired sugar metabolism). It is recommended to assess the adequacy of the growth hormone dose every 6 months.